Host factors that modify Plasmodium falciparum adhesion to endothelial receptors
نویسندگان
چکیده
منابع مشابه
Host response to cytoadherence in Plasmodium falciparum.
Cytoadherence of PRBCs (Plasmodium falciparum-infected red blood cells) to host endothelium has been associated with pathology in severe malaria, but, despite extensive information on the primary processes involved in the adhesive interactions, the mechanisms underlying the disease are poorly understood. Endothelial cells have the ability to mobilize immune and pro-adhesive responses when expos...
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The clinical complications associated with severe and cerebral malaria occur as a result of the intravascular mechanical obstruction of erythrocytes infected with the asexual stages of the parasite, Plasmodium falciparum. We now report that a primary P. falciparum-infected erythrocyte (parasitized red blood cell [PRBC]) isolate from a patient with severe complicated malaria binds to cytokine-in...
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In vivo and in vitro assessments of the response of P. falciparum to chloroquine using WHO standard kits and techniques were carried out in I ran Shahr, Sistan and Baluchestan province of Iran in 1985. In the in vivo assessment, 24 malaria patients treated with chloroquine (25mg/kg over three days) were followed up for one to four weeks. The mean parasite clearance time was 4.3 days and in...
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During Plasmodium falciparum malaria infections, von Willebrand factor (VWF) levels are elevated, postmortem studies show platelets colocalized with sequestered infected erythrocytes (IEs) at brain microvascular sites, whereas in vitro studies have demonstrated platelet-mediated IE adhesion to tumor necrosis factor-activated brain endothelium via a bridging mechanism. This current study demonst...
متن کاملCharacteristics of Plasmodium falciparum-infected-erythrocyte adhesion to chondroitin sulfate.
In a recent article in Infection and Immunity, Madhunapantula et al. stated that the characteristics of adhesion of Plasmodium falciparum-infected erythrocytes (IEs) to chondroitin4-sulfate (C4S) at different stages of parasite development were not known (6), and they presented findings that examined these properties. However, those authors have overlooked earlier reports that documented the ef...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/s41598-017-14351-7